lH5JWy}DgKRR"Fs The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. MATERIAL SAFETY DATA SHEET. Eur., JPE . ]2}Sb2Wdn-;^}n(/;r\'l3--l~
kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . endobj
The short-term limit for total inhalable dust is 20 mg/m3. 2021 Annual Report. Microcrystalline Cellulose. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. : 9004-34-6 Date Approved: 01/31/2008 . To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. common form is used in vitamin supplements or tablets. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Product Name: Microcrystalline Cellulose E460 1.2. : CL-611NF Date Approved: 01/13/2010. endobj
Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . %PDF-1.3 Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. MATERIAL SAFETY DATA SHEET Version: 1.0 1. Hi, let us know if you have any questions as you visit our website. Delivering efficient and robust formulations. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. Gloves, eye protection and a dust mask should be used. G2W4de=u183KGH{ vQ#4:1\wc Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. ( In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. (Microcrystalline Cellulose Market Pr. <>
iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. If you are already a ChemPoint customer then sign up for access to our online ordering website. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . Avicel PH-101. pH 6.0 to 8.0 . 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC
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Manufacturer: FMC BioPolymer. It is, however, a good source of fibre. No. No. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Microcrystalline Cellulose Side Effects. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. Chemical Formula: (C6H10O5)n 1.4. Home. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. : 160182. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. (1962). These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. . MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. No. Microcrystalline Cellulose / Avicel PH-102. stream
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%QL((((((((((((((((((((((((((((((((((((((((P3NhC FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. We can send by Fedex, by ship or by plane according to international rules. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Production of Pharmaceutical Grade Microcrystalline Cellulose. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. <<
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[#B6`Wnw7 Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. endobj
The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. <<
Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . };khd5x=fr Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. Safety Data Sheet (SDS) Viewer. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0
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Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. Your file is uploaded and ready to be published. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Product Name Cellulose microcrystalline. SCMm_>x^O9l (n. Microcrystalline Cellulose (MCC) Manufacturing Industry. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C
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g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! LOT #: Available upon request. The data shown below apply only to Avicel PH 101. : 160182 Date Approved: 05/25/2010 Revision No. Packaging: 34 x 50 kgs fiber drums. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. Dyvo5bp#bR W7~IF C"
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Ur?0J. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. 8 0 obj Microcrystalline cellulose (C6H10O5)n is refined wood pulp. It is . The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. It is hygroscopic and insoluble in water. stream CAS #: 9004-34-6 . The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . Learn about FMC's industry leading goal of net-zero emissions by 2035. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Avicel PC 611 (FMC Biopolymer) . PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. 6 0 obj
They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Origin(s): Plant/Botanical. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. undefined. Molecular Weight null. ). . : 1. /Resources 2 0 R
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By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. CAS No. It works as a moisture sponge and permits the controlled growth of spheroids.
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